WebMolecular. The TREX1 gene consists of a single exon, and its location on chromosome 3. TREX1 encodes a protein with 314 amino acids in length, and the only known post-translational modification of TREX1 is monoubiquitination by ubiqulin1 which regulates its endoplasmic reticulum localization.. The TREX1 enzyme exists as a homodimer like many … http://www.reactome.org/content/detail/R-HSA-3244651
Familial chilblain lupus due to a novel mutation in TREX1 …
WebJan 9, 2024 · Three-prime repair exonuclease 1 knockout (Trex1 −/−) mice suffer from systemic inflammation caused largely by chronic activation of the cyclic GMP-AMP synthase–stimulator of interferon genes–TANK-binding kinase–interferon regulatory factor 3 (cGAS–STING–TBK1–IRF3) signaling pathway.We showed previously that Trex1 … WebApr 6, 2007 · The TREX1 enzyme processes DNA ends as the major 3′ → 5′ exonuclease activity in human cells. Mutations in the TREX1 gene are an underlying cause of the neurological brain disease Aicardi-Goutières syndrome implicating TREX1 dysfunction in an aberrant immune response. TREX1 action during apoptosis likely prevents autoimmune … family homeless shelters in tampa florida
TREX1 related genes - GeneCards Search Results
WebJan 7, 2024 · TREX1 is an exonuclease that degrades extranuclear DNA species in mammalian cells. Herein, we show a novel mechanism by which TREX1 interacts with the BiP/GRP78 and TREX1 deficiency triggers ER stress through the accumulation of single-stranded DNA and activates unfolded protein response (UPR) signaling via the disruption … WebGeneCards: TREX1: GeneTests: TREX1: Orphanet: TREX1: Active transcripts. Legend Please note that a short description of a certain column can be displayed when you move your mouse cursor over the column's header and hold it still. Below, a more detailed description is shown per column. WebJan 6, 2024 · The GeneCards® database of human genes was launched in 1997 (Rebhan et al. 1997) and has expanded since then to encompass gene-centric, disease-centric, and pathway-centric entities and relationships within the GeneCards Suite, effectively navigating the universe of human biological data—genes, proteins, cells, regulatory elements, … family homeless shelters in maryland