The pleiotropic benefits of statins

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Webb22 juli 2024 · As a result of their pleiotropic effects statins modulate virtually all known processes of atherosclerosis and have beneficial effects outside the cardiovascular … Webb9 nov. 2024 · Despite prior analyses suggesting that the cardiovascular benefits of statins are mediated mainly by the reduction in LDL-C (LDL cholesterol), 1 there has been ongoing debate as to whether the observed benefits and risks of statins are mediated exclusively via their LDL lowering properties or whether other pleiotropic mechanisms come into …

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Webb1 okt. 2012 · In recent years, however, a number of additional non-lipid-lowering, or ‘pleiotropic’, effects of statins have been suggested to contribute to their efficacy in … Webb17 okt. 2024 · However, the clinical benefit of statin-induced elevation of HDL-cholesterol is unclear from trial data, ... statins have pleiotropic benefits including prevention of LDL oxidation. View full-text. simons lane frodsham

Pleiotropic effects of statins Tandon V, Bano G, Khajuria V, Parihar …

Webb6 maj 2016 · These may be predicted as harmful or beneficial effects of the drug. The most wonderful positive pleiotropic effects of statins are anti-inflammatory, anti-proliferative, antithrombotic, improving endothelial dysfunction, and neuroprotective besides many others (Lewington et al. 2007; DuBroff and De Lorgeril 2015 ). Webb25 mars 2024 · The pleiotropic benefits of statins include the ability to reduce CD47 and amplify the effect of pro-efferocytic therapies in atherosclerosis. Nat. Cardiovasc. Res. 1, … WebbAlong with lipid-lowering potency, the beneficial pleiotropic effects of statins, such as the antibacterial and immunomodulatory properties, may act in a dose-dependent fashion. … simons island vacation

Investigating the effects of statins on ischemic heart disease

WebbPleiotropic effects of statins include improvement of endothelial dysfunction, increased nitric oxide bioavailability, antioxidant properties, inhibition of inflammatory responses, … Webb19 apr. 2010 · This article is part I of a 2-part review, and it focuses on the pleiotropic effects of statins at the cellular level. References. Buhaescu I., Izzedine H. Mevalonate pathway: a review of clinical and therapeutical implications . ... Statins: Risk-Benefits and Role in Treating Dyslipidemias. simon skjodt assembly hall eventsWebb8 apr. 2024 · The greatest improvements were recorded in the fluvastatin and dual therapy groups, suggesting the statin had played a dominant role. 28 Remarkably, a significant increase in nitric oxide and reduction in endothelin-1 was observed in the two groups receiving statins, indicating that the pleiotropic effects of this drug are fundamental for … simon slater chef

"WebbCurrently, new benefits of statins, not dependent on the reduction of LDL cholesterol, have been proposed in the setting of ACS. These effects, which are not dependent on the reduction of LDL cholesterol, are called pleiotropic [Liao, 2005]. Some of the possible effects of statins, which may participate in the benefits that they represent for " - The pleiotropic benefits of statins

The pleiotropic benefits of statins

[PDF] Effects of statins on nitric oxide/cGMP signaling in human ...

Webb15 mars 2024 · Ultimately, the benefits of statins in an infection setting appear to require attention to the underlying host response and to the timing of the dosage. From this … WebbSaeid Ghavami Associate Editor at Elsevier, Frontiers, PLOS, and MDPI publishing group

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WebbMost pleiotropic effects of statins in cell cultures can be reversed by the addition of mevalonate. Effects that are mediated by Rho GTPases are attributed to the isoprenoid, …

Webb1 okt. 2014 · Recent experimental and clinical evidence indicates that some of the cholesterol-independent or "pleiotropic" effects of statins involve improving or restoring endothelial function, enhancing the stability of atherosclerotic plaques, and decreasing oxidative stress and vascular inflammation. 1,280 PDF Webb1 maj 2024 · The so-called pleiotropic effects are mediated by the reduction of isoprenoids, such as farnesyl-pyrophosphate and geranylgeranyl-pyrophosphate, necessary for the activation of small GTPases like Rho and Ras proteins (Fig. 1A).Statins diversely inhibit RhoA and Rac1 prenylation, modulating endothelial nitric oxide (NO) synthase …

Webb30 nov. 2024 · Of note, statin treatment possesses the ability to make an immediate impact in patient care. Clinical trials with statins reveal conflicting results, but overall … WebbDOI: 10.1016/S1734-1140(10)70247-4 Corpus ID: 4742496; Effects of statins on nitric oxide/cGMP signaling in human umbilical vein endothelial cells. @article{Meda2010EffectsOS, title={Effects of statins on nitric oxide/cGMP signaling in human umbilical vein endothelial cells.}, author={Claudia Meda and Christian Plank and …

Webb17 sep. 2015 · “Pleiotropic" effects of statins involve improving endothelial function, decreasing vascular inflammation and oxidative stress, and inhibiting the thrombogenic …

Webb7 apr. 2024 · Request PDF The pleiotropic effects of statins in rheumatoid arthritis Objectives: Rheumatoid arthritis (RA) is an inflammatory and autoimmune disease. Studies over the past two decades ... simons lane shipton under wychwoodWebb12 juni 2015 · This finding “suggests that reduction of LDL cholesterol levels per se explains the effect of statins on coronary heart disease,” rather than some pleiotropic benefit specific to statins, the editorialists wrote. “It’s nice to have all the different options for patients,” Cannon said. simons jewelry huntsville alWebbStatins exert pleiotropic effects on the cardiovascular system, in part through an increase in nitric oxide (NO) bioavailability. AMP-activated protein kinase (AMPK) plays a central role in controlling energy and metabolism homeostasis in various organs. We therefore studied whether statins can activate AMPK, and if so, whether the activated ... simons landbouwmachinesWebbRajagopal et al. / Cumhuriyet Dental Journal, 25(2): 200-205, 2024 201 Table 1. History of Statins YEAR INVENTION 1784 François Poulletier, a French doctor-chemist obtained real cholesterol from ... simon sky sports newsWebb10 mars 2015 · In summary, statins are probably both under- and over-utilized in older adults. For example, it is estimated that only 40-60% of patients over 65 are prescribed a statin after an acute MI; 24 conversely, a recent study found that 30% of patients with a cancer diagnosis were dispensed a statin within 30 days of dying. 25 For primary … simons laufer mathematical sciences instituteWebbThe pleiotropic benefits of statins may result from their impact on vascular inflammation. The molecular process underlying this phenomenon is not fully elucidated. Here, RNA … simons lawn care and maintenanceWebbConcerns about the hazards of statins on the development and mortality of stomach cancers remain controversial. Here, we investigated the likelihood of incident gastric cancers and related mortality depending on statin exposure, statin type, and the duration of use. This nested case–control-designed study was composed of 8798 patients who … simons lawn mower