WebPurpose: Mutations in the EGFR (epidermal growth factor receptor) gene can guide the choice of therapy in patients with non-small cell lung cancer (NSCLC). Clinically relevant mutations occur in exons 18, 19, 20 and 21 of the gene. Gene fusions leading to overexpression of the ALK or ROS1 genes also have implications regarding choice of … WebMar 1, 2024 · SHH-MBs are characterized by pathogenic activation of SHH signaling. ... disorder caused by germline inactivation of PTCH1 or SUFU that is associated with an increased risk of development of skin cancer and MB during adolescence or early ... Sonic hedgehog MBs (SHH-MBs) contain multiple cell types, including granule neuron ...
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Sonic Hedgehog Signaling in Organogenesis, Tumors, and Tumor ...
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