Sin3b cancer
WebbSin3B was associated with delayed PDAC progression and correlated with an impaired inflammatory response. In murine and human pancreatic cells and tissues, levels of … Webb10 nov. 2016 · These observations suggest that Sin3B functions as a non-classical tumor suppressor which serves to limit the transformative potential of cancer cells. The restoration of Sin3B functionality and downstream pathways may prove useful in the design of targeted therapies to treat advanced disease.
Sin3b cancer
Did you know?
Webb13 aug. 2012 · We show that Sin3A is downregulated in a variety of human tumors and that Src, JNK, RhoA and PP1B/β-Catenin are regulated in a manner analogous to our … Webb29 mars 2024 · Senescence-associated SIN3B promotes inflammation and pancreatic cancer progression the essential role of Sin3B as an important associate of p53 in …
Webb8 aug. 2014 · In leukemia cells and fibroblasts, Sin3b silencing led to Myc up-regulation, whereas Sin3b overexpression induced Myc deacetylation and degradation. An analysis of Sin3b expression in breast tumors revealed an association between low Sin3b expression and disease progression. Webb9 okt. 2024 · Sin3B serves as a scaffold for chromatin-modifying complexes that repress gene transcription to regulate distinct biological processes. Sin3B-containing complexes …
WebbSIN3B. The antibodies are designated mAB for monoclonal and pAb for polyclonal. The release of the Human Protein Atlas in which the antibody was first published. All assays through which the antibody has been validated. Assays&annotation provide a detailed description of the different assays. The pie-charts indicate degree of validation.
WebbWe previously demonstrated that the histone deacetylase-associated protein SIN3B is essential for oncogene-induced senescence in cultured cells. Here, using a mouse model …
Webb4 dec. 2024 · Human cancer cells lacking Sin3B were, however, able to enter quiescence normally and progress through the cell cycle with normal kinetics. Strikingly, ectopic expression of the APC/C CDH1 inhibitor EMI1 was sufficient to promote cell-cycle re-entry of Sin3B deleted cells under serum-deprived conditions, while the Sin3B wild-type cells … esskay hot dogs nutritionWebb8 dec. 2024 · Sin3B is required for the senescent phenotype and elevated levels of reactive oxygen species elicited upon Bmi-1 depletion. Senescence-associated SIN3B promotes inflammation and pancreatic cancer progression interaction with Sin3B influences Na (v)-channel trafficking or stability in the membrane. esskay creamed chipped beef packetsWebbExpression of SIN3B (KIAA0700) in cancer tissue. The cancer tissue page shows antibody staining of the protein in 20 different cancers. We use cookies to enhance the usability … esskay design and structuresWebb29 nov. 2016 · SIN3 corepressor complexes play important roles in both normal development and breast cancer. Mammalian cells have two paralogs of SIN3 (SIN3A … esskay logisticsWebb1 jan. 2016 · Sin3B also interacts with an E3 ubiquitin ligase, RNF220 that targets Sin3B for ubiquitination and promotes its proteasomal degradation (Kong et al., 2010). Recently … esskay pharmaceuticals ltd share priceWebb1 juli 2008 · These observations strongly suggest that Sin3B plays an essential role in coordinating the chromatin modifying activities required for the transient repression of pro-proliferation genes in... fireball photoshopWebb12 aug. 2009 · Importantly, expression of Sin3B increases upon oncogenic stress, both in vitro and in vivo, correlating with the induction of the senescence program, but is … esskay international