Qki srebp2
TīmeklisQki activates Srebp2-mediated cholesterol biosynthesis for maintenance of eye lens transparency. Association of SREBF-2 gene polymorphisms with the risk of … TīmeklisQki regulates myelinogenesis through Srebp2-dependent cholesterol biosynthesis . Xin Zhou, Seula Shin, Chenxi He, Qiang Zhang, Matthew N Rasband, Jiangong Ren, Congxin Dai, Rocío I Zorrilla-Veloz, Takashi Shingu, Liang Yuan,Yunfei Wang, Yiwen Chen, Fei Lan, Jian Hu. Nature Communications, 2024
Qki srebp2
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TīmeklisMechanistically, Qki-5 functions as a co-activator of Srebp2 to control transcription of the genes involved in cholesterol biosynthesis in oligodendrocytes. Consequently, Qki depletion led to substantially reduced concentration of cholesterol in mouse brain, impairing proper myelin assembly. Our study demonstrated that Qki-Srebp2 … TīmeklisRegjistrimi bëhet duke shtypur në linkun Regjistrohu dhe duke plotësuar të dhënat e kërkuara. Pas plotësimit të të dhënave, ju dërgohet një email për konfirmimin e …
Tīmeklis2024. gada 4. janv. · The RNA-binding protein QKI belongs to the hnRNP K-homology domain protein family, a well-known regulator of pre-mRNA alternative splicing and is associated with several neurodevelopmental disorders. Tīmeklis2024. gada 21. maijs · It is proposed that Qki-Srebp2–mediated cholesterol biosynthesis is essential for maintaining the cholesterol level that protects lens from cataract development. Defective cholesterol biosynthesis in eye lens cells is often associated with cataracts; however, how genes involved in cholesterol biosynthesis …
Tīmeklis2024. gada 23. maijs · We found the genome-wide co-binding of QKI-5 and SREBP2. Notably, the genomic distribution analysis revealed that the co-binding events between QKI-5 and SREBP2 highly occurred at the regions of the promoter/transcription start site (TSS), where active transcription was taken place in a lens cell-specific manner, … TīmeklisMechanistically, we demonstrate that Qki enhances cholesterol biosynthesis by recruiting Srebp2 and Pol II in the promoter regions of cholesterol biosynthesis genes. Supporting its function as a transcription co-activator, we show that Qki directly interacts with single-stranded DNA.
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TīmeklisInhibition of Osteoclastogenesis by the RNA-Binding Protein QKI5: a Novel Approach to Protect from Bone Resorption. Diabetic endotheliopathy: RNA-binding proteins as … black phone characters robinTīmeklisMechanistically, Qki-5 functions as a co-activator of Srebp2 to control transcription of the genes involved in cholesterol biosynthesis in oligodendrocytes. Consequently, … black phone chat linesTīmeklis2024. gada 4. maijs · Search worldwide, life-sciences literature Search. Advanced Search Coronavirus articles and preprints Search examples: "breast cancer" Smith … black phone chat lines 60 min free