WebPhenytoin is used to control certain type of seizures, and to treat and prevent seizures that may begin during or after surgery to the brain or nervous system. Phenytoin is in a class of medications called anticonvulsants. It works by decreasing abnormal electrical activity in … WebToxicokinetics. Phenytoin is slowly but nearly completely absorbed in the small intestine; oral bioavailability ranges from 70 to 100%. The drug is widely distributed in the body and is almost completely protein-bound, primarily to albumin. Phenytoin is metabolized primarily …
Appendix 10: Administering drugs via feeding tubes
WebJul 15, 2002 · They may inhibit the absorption of drugs such as griseofulvin (Grisactin), ketoconazole (Nizoral), itraconazole (Sporanox), iron salts, vitamin B 12, cefpodoxime (Vantin), and enoxacin (Penetrex ... WebPhenytoin (Dilantin, Dilantin Infatabs, Phenytek) Folate: Phenytoin inhibits the intestinal absorption of folate and lowers serum folate concentrations. Supplementation with high-dose folic acid may lead to decreased serum concentrations of phenytoin. ... Iron from food or supplements may decrease absorption of the antibiotic due to chelate ... cdc health risk appraisal
Side effects of phenytoin - NHS
WebIron-extracted maize fibers (Ftw/Fe) bound significantly more iron than Ftc/Fe, FDA and FDN correspondingly (P less than 0.001). Phenytoin bound significantly more iron than total maize fibers both, with and without previous iron extraction (P less than 0.001). Also, phenytoin combined with maize-fiber bound less iron than phenytoin alone in G.S.A. Webphenytoin concentrations may be more useful in these patient populations. Age: Phenytoin clearance tends to decrease with increasing age (20% less in patients over 70 years of age relative to that in patients 20-30 years of age). Phenytoin dosing requirements are highly variable and must be individualized (see DOSAGE AND ADMINISTRATION). WebEffect of iron deficiency anaemia and its treatment on single dose phenytoin bioavailability Iron deficiency is a common nutritional deficiency, which leads to structural functional and enzymatic changes in the body that may affect the pharmacokinetics of drugs. butler commission upsc