WebCystatin C-based eGFR for drug dosing Our nephrology team is encouraging a shift towards Cystatin C-based eGFR for drug dosing. One of our concerns is around practicing "off-label" since most FDA approved dosing is based on CrCl cut-offs. Has this been evaluated at your institution? WebCystatin C is a protein that is produced by the cells in your body. When kidneys are working well, they keep the level of cystatin C in your blood just right. If the level of cystatin C in your blood is too high, it may mean that your kidneys are not working well.
Vancomycin Dosing Based on eGFR (creatinine-cystatin C) - Medscape
WebThe effect of obesity on both renal function and drug pharmacokinetics raises the issue of correct drug dosage in obese individuals. This may be particularly relevant for drugs known to have a narrow therapeutic range or excreted by the kidney. Key ... Therefore, the use of cystatin C as a surrogate marker of GFR needs further evaluation ... Webequations and cystatin C-based equations (ICCs 0.54 to 0.76). When comparing the five different references consulted to identify necessary drug dose adjustments we found that the numbers of drugs that necessitate dose adjustment in the case of renal impairment differed considerably. The mean number of recommended changes in drug dosage how many times can a governor serve
Cystatin C is ready for clinical use - PubMed
WebJul 1, 2024 · Cystatin C, drug dosing and effective patient treatment Monitoring patient's cystatin C levels can improve patient treatment and shorten the recovery time. Correct dosing can therefore create cost … WebJul 29, 2024 · Aakjær M, Houlind MB, Treldal C, et al. Differences in kidney function estimates based on creatinine and/or cystatin C in non-traumatic amputation patients … WebNumerous studies have evaluated medication dosing based on either GFR estimate; vancomycin was the most frequently studied drug and its target level and elimination were better predicted by cystatin C. Overall, … how many times can a honey bee sting a human