WebApr 7, 2024 · In this study, we conducted genome-wide CRISPR-Cas9-based knockout screens to investigate secondary hits that lead to uncontrolled proliferation and tumorigenic growth in TP53 -deficient cells. We identified many components of the ubiquitination/neddylation pathway resulting in enhanced proliferation when inactivated. WebWe show that KCTD7 works in complex with Cullin-3 and Rbx1 to execute atypical, non-degradative ubiquitination of calpains at specific sites (K398 of calpain 1, and K280 and K674 of calpain 2). Experiments based on single-lysine mutants of ubiquitin determined that KCTD7 mediates ubiquitination of calpain 1 via K6-, K27-, K29-, and K63-linked ...
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WebHuman ANPEP (CD13) knockout THP-1 cell line (ab273759) Description: Human ANPEP (CD13) knockout THP-1 cell line. Application: Flow Cyt, ICC, WB. Compare (max 4) WebMar 21, 2024 · Enables cullin family protein binding activity. Involved in cellular response to DNA damage stimulus; positive regulation of protein neddylation; and regulation of cell growth. Located in nucleus and spindle. [provided by Alliance of Genome Resources, Apr 2024] GeneCards Summary for DCUN1D5 Gene im feldle 3 calw
Cells Free Full-Text CUL4-DDB1-CRBN E3 Ubiquitin Ligase …
WebJan 5, 2024 · The role of cullin E3-ubiquitin ligases for muscle homeostasis is best known during muscle atrophy, as the cullin-1 substrate adaptor … WebMar 21, 2024 · CUL9 (Cullin 9) is a Protein Coding gene. Diseases associated with CUL9 include Amelogenesis Imperfecta, Hypomaturation Type, Iia3 and Three M Syndrome 1.Among its related pathways are Metabolism of proteins and Class I MHC mediated antigen processing and presentation.Gene Ontology (GO) annotations related to this gene … WebNov 16, 2024 · Abundance of PD-L1, the ligand of the anti-cancer immunotherapy target PD-1, is negatively regulated by poly-ubiquitination via the cyclin D–CDK4/cullin 3–SPOP axis and PD-1 blockade treatment ... imfeld credit suisse