Cisplatin magnesium wasting

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August undefined, 2024

WebFeb 1, 1999 · Cisplatin induces hypomagnesemia through its renal toxicity possibly by a direct injury to mechanisms of magnesium reabsorption in the ascending limb of the loop of Henle as well as the distal tubule. Since the magnesium reabsorption process still remains to be fully characterized, the effect by cisplatin on this process remains uncertain. WebCisplatin (cis-diamminedichloroplatinum II), a chemotherapeutic agent used against epithelial neoplasms, is known to cause hypomagnesemia and renal magnesium …

Cisplatin - an overview ScienceDirect Topics

WebSodium and potassium disorders are pervasive in patients with cancer. these abnormalities are wide-ranging, are often primary or second-order consequences of the underlying cancer, and have prognostic implications. The approach to hyponatremia should focus on cancer-related etiologies, such as syndrome of inappropriate antidiuretic WebJul 11, 2003 · Cisplatin is not directly toxic to bone, but cisplatin nephrotoxicity leading to magnesium wasting may affect magnesium and calcium metabolism, both of which contribute to bone integrity. The specificity of the magnesium lesion suggests that cisplatin may have an affinity for proteins that regulate magnesium absorption. dallas buyers club online gratis

Magnesium Depletion - an overview ScienceDirect Topics

WebRenal magnesium wasting may be part of a primary inherited disorder (Gitelman's syndrome),12, 13a single defect in magnesium reabsorption,14or associated with several other clinical disorders.2, 4Excessive urinary losses of magnesium can also be associated with diabetic ketoacidosis, hyperaldosteronism, hypercalciuria (with concomitant use of … WebOct 1, 2024 · Cisplatin injury to renal tubules often impacts magnesium reabsorption, resulting in renal magnesium wasting and hypomagnesemia . Earlier studies suggest that cisplatin induces hypomagnesemia in 40–90% of patients receiving the treatment, and magnesium loss in turn aggravates cisplatin nephrotoxicity ( 3 , 5 ). WebMagnesium plays an important role in the maintenance of intracellular K. An unrecognized and untreated Mg depletion can lead to a refractory K repletion. We describe two patients with hypomagnesemia-associated refractory hypokalemia following cisplatin therapy. Potassium supplementation failed to replace the K deficit. dallas buyers club movie cast

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Cisplatin and hypomagnesemia - PubMed

WebMay 19, 2024 · Aminoglycosides: Can cause renal magnesium wasting and subsequent deficiency . Antibiotics: ... Cisplatin-based chemotherapy: May cause hypomagnesemia . Dasatinib: May increase blood levels of … Webwasting due to cisplatin therapy. Although patients with cancer have hyponatremia due to many etiologies (Table 1), SIADH is the most common etiol- ... drugs, where renal magnesium wasting can be permanent. Hypercalcemia Twenty percent to 30% of cancer patients experience hypercal-cemia during the course of their malignancy (19), and this is dallas buyers club mcconaughey weight lossWebJan 12, 2024 · Hypomagnesemia is often associated with hypokalemia (due to urinary potassium wasting) and hypocalcemia (due both to lower parathyroid hormone secretion … bippity boppity sequim

"WebSep 1, 1986 · Cisplatin (cis-diamminedichloroplatinum II), a chemotherapeutic agent used against epithelial neoplasms, is known to cause hypomagnesemia and renal magnesium wasting. In order to further characterize the effect of multiple doses of this drug upon serum magnesium levels and renal magnesium handling, we prospectively studied 28 patients … " - Cisplatin magnesium wasting

Cisplatin magnesium wasting

WebWe documented inappropriate renal magnesium wasting in four patients. Two patients required hospitalization for symptomatic hypomagnesemia. We conclude that cisplatin … WebNational Center for Biotechnology Information

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WebApr 5, 2024 · Magnesium is another supplement that has been shown to be helpful in reducing cisplatin related toxicity. Solanki et al. have noted in their mice studies that a deficiency of magnesium amplifies markers of renal damage which is promptly reversed by supplementation with magnesium. WebAug 16, 2024 · A single-region retrospective study from central Texas at Baylor Scott & White Cancer Clinics who were treated with two or more cycles of cisplatin were included. Standard hydration for this study was defined as normal saline before and after cisplatin along with potassium chloride 10 mEq and magnesium sulfate 1 g added to the …

WebIn a retrospective cohort of adult cancer patients receiving cisplatin, those who received magnesium supplementation IV experienced a statistically significant reduction in nephrotoxicity (6 ... Adelstein DJ. Hypomagnesemia and renal magnesium wasting in patients treated with cisplatin. Am J Kidney Dis. 1986; 8:164–169. doi: 10.1016/S0272 … WebHypomagnesemia is a common side effect of cisplatin occurring . in 90% of patients by the fourth cycle of treatment caused by renal tubular damage leading to increased renal wasting of magnesium if no corrective measures are taken [1]. Cisplatin causes damage to calcium and magnesium sensing receptors at level of thick ascending

WebCisplatin is a chemotherapy drug used to treat some forms of cancer. Note: ... Severe magnesium deficiency caused by cisplatin therapy has been reported to result in … Web42%–100% of patients depending on total cisplatin dose and length of exposure. Hypomagnesemia and renal magnesium wasting may persist for up to 6 years after initial dose (5). Renal salt wasting syndrome has been reported in up to 10% of patients, manifesting as hyponatremia and severe ortho-static hypotension in the setting of high …

WebCisplatin is a coordinate metal complex with significant antineoplastic activity and various effects, including acute anc chronic renal insufficiency and renal magnesium wasting. Nephrotoxicity may occur in as many as 50% to 75% of patients receiving the drug, and is apparently due to renal tubular injury. dallas buyers club online subtituladaWebAbstract. Purpose: Administration of cisplatin causes changes in magnesium and potassium metabolism. The purpose of this study was to investigate day-to-day changes in renal and intestinal homeostasis of magnesium (Mg) and potassium (K) during repeated cisplatin treatments in rats to provide guidelines for human supplementation studies. bippity boppity women are propertyWebOct 1, 2024 · Some authors point to the beneficial effect of magnesium supplementation in fluid therapy employed before and after the administration of cisplatin/carboplatin (magnesium supplementation... dallas buyers club movie imagesWebFeb 1, 1999 · Since the magnesium reabsorption process still remains to be fully characterized, the effect by cisplatin on this process remains uncertain. … dallas buyers club movie trailerWebSep 9, 2024 · 17q12 deletion syndrome encompasses a broad constellation of clinical phenotypes, including renal magnesium wasting, maturity-onset diabetes of the young (MODY), renal cysts, genitourinary malformations, and neuropsychiatric illness. Manifestations outside of the renal, endocrine, and nervous systems have not been well … bippity bunny and the big bullyWebFeb 5, 2014 · Cisplatin is one of the most potent and valuable chemotherapy agents available, and is used to treat a broad spectrum of malignancies, with cisplatin … bippity bottomWebCisplatin (cis-diamminedichloroplatinum II), a chemotherapeutic agent used against epithelial neoplasms, is known to cause hypomagnesemia and renal magnesium wasting. In order to further characterize the effect of multiple doses of this drug upon serum magnesium levels and renal magnesium handling, we prospectively studied 28 patients … bippity boppity your now my property