WebProliferation, Viability and Migration in Vitro ... Two critical downstream effectors,CDK4 and CCND2 was attenuated in MTHFD2-decienct cells. Overexpression of MYC rescured the inhibitory effects of MTHFD2 deciency in the CCND2 and CDK2 expression. Conclusion: Overall, we rst uncovered that MTHFD2 could play a protumor role in bladder cancer by ... WebAt least seven mutations in the CCND2 gene have been found to cause megalencephaly-polymicrogyria-polydactyly-hydrocephalus (MPPH) syndrome. This rare condition affects …
Cyclin D2 - Wikipedia
WebMar 29, 2024 · Go to Variation Viewer for CCND2 variants Summary The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. WebAug 12, 2024 · CCND2 as a member of the cell cycle family, its abnormal expression may lead to abnormal cell proliferation. Studies have found that CCDN2 is abnormally expressed in a variety of tumor tissues, such as cervical cancer [ 27 ], gastric cancer [ 28 ], non-small cell lung cancer [ 29 ], and prostate cancer [ 30 , 31 ]. bluff life
LncRNA XIST acts as a ceRNA sponging miR-185-5p to modulate …
WebNov 25, 2024 · To determine how the expression levels of Ccnd2, Dnmt1, Tet2, and Lhcgr were regulated in granulosa cells during follicular development, granulosa cells were … WebJan 5, 2024 · Methods and results: Human CCND2 was delivered to hiPSCs via lentiviral-mediated gene transfection. In cultured cells, markers for cell cycle activation and … WebMegalencephaly- polymicrogyria -polydactyly-hydrocephalus (MPPH) syndrome is a rare disorder that primarily affects the development of the brain. Affected individuals are born with an unusually large brain and head size (megalencephaly). The head and brain continue to grow rapidly during the first 2 years of life. bluff landing corpus christi