WebArginase I is the more abundant isozyme of the two, and it has been extensively characterized in terms of its biochemistry, enzymology, and three-di mensional structure. … WebApr 24, 2002 · The hyperthermophilic archaeon Methanococcus jannaschii uses several non-canonical enzymes to catalyze conserved reactions in glycolysis and …
A metalloenzyme reloaded Nature Chemical Biology
WebOct 20, 2009 · Binuclear manganese enzymes are a small group of enzymes that catalyze a variety of chemical reactions and are involved in numerous metabolic functions. ... WebJun 23, 2024 · Repair of Iron Center proteins (RIC) form a family of di-iron proteins that are widely spread in the microbial world. RICs contain a binuclear nonheme iron site in a four-helix bundle fold, two basic features of hemerythrin-like proteins. In this work, we review the data on microbial RICs including how their genes are regulated and contribute to the … safe house for abused women
A versatile artificial metalloenzyme scaffold enabling …
WebMar 15, 2024 · Almost all known potent inhibitors of this monotrimeric binuclear manganese metalloenzyme interact with the pocket entrance and contain a warhead that binds deep into the pocket to interact with the metal coordination network. The common core and R1 groups of the 1,3,4-pyrrolidine hits reported here engages the entrance of the pocket … WebMar 9, 2004 · Request PDF Asymmetry in Bridged Binuclear Metalloenzymes: Lessons for the Chemist This microreview describes the structures, properties and mechanisms of … WebOpdA is a binuclear metalloenzyme that can hydrolyze organophosphate pesticides and nerve agents. In this study the crystal structure of the complex between OpdA and phosphate has been determined to 2.20 Å resolution. The structure shows the phosphate bound in a tripodal mode to the metal ions whereby two of the oxygen atoms of PO(4) are ... safe house bodyguard